Fluoxetina [Inn-Spanish]
Brand names,
Fluoxetina [Inn-Spanish]
Analogs
Fluoxetina [Inn-Spanish]
Brand Names Mixture
Fluoxetina [Inn-Spanish]
Chemical_Formula
C17H18F3NO
Fluoxetina [Inn-Spanish]
RX_link
http://www.rxlist.com/cgi/generic/fluoxetine.htm
Fluoxetina [Inn-Spanish]
fda sheet
Fluoxetina [Inn-Spanish]
msds (material safety sheet)
Fluoxetina [Inn-Spanish]
Synthesis Reference
B. B. Mally; K. K. Schmiegel; U.S. Pat. 4,314,081 (1982)
Fluoxetina [Inn-Spanish]
Molecular Weight
309.326 g/mol
Fluoxetina [Inn-Spanish]
Melting Point
179-182oC
Fluoxetina [Inn-Spanish]
H2O Solubility
50 mg/mL at 25°C
Fluoxetina [Inn-Spanish]
State
Solid
Fluoxetina [Inn-Spanish]
LogP
5.37
Fluoxetina [Inn-Spanish]
Dosage Forms
Capsule; Liquid; Solution
Fluoxetina [Inn-Spanish]
Indication
For the treatment of depression, obsessive compulsive disorder, and bulimia nervosa.
Fluoxetina [Inn-Spanish]
Pharmacology
Fluoxetine, an antidepressant agent belonging to the selective serotonin reuptake inhibitors (SSRIs), is used to treat depression, bulimia nervosa, premenstrual dysphoric disorder, panic disorder and post-traumatic stress. According to the amines hypothesis, a functional decrease in the activity of amines, such as serotonin and norepinephrine, would result in depression; a functional increase of the activity of these amines would result in mood elevation. Fluoxetine's effects are thought to be associated with the inhibition of 5HT receptor, which leads to an increase of serotonin level.
Fluoxetina [Inn-Spanish]
Absorption
72%
Fluoxetina [Inn-Spanish]
side effects and Toxicity
Symptoms of overdose include agitation, restlessness, hypomania, and other signs of CNS excitation. LD50=284mg/kg (orally in mice).
Fluoxetina [Inn-Spanish]
Patient Information
Fluoxetina [Inn-Spanish]
Organisms Affected
Humans and other mammals